Disclaimer: Note that the firm is no longer accepting cases for the anti-psychotic medication Abilify or Tylenol autism cases. Thank you.
Select Page

The Adverse Effects of Paraquat (Part 3)

History of Paraquat 

Paraquat was first produced for commercial purposes in 1961.[1] In the United States, Paraquat is only available to be used by licensed applicators for commercial purposes. That is because it is a restricted-use herbicide.

Paraquat and Oxidative Stress

A significant cause of Parkinson’s disease is a loss of function of the dopamine neurons in the brain called the substantia nigra pars compacta. The brain cells in this part of the brain are especially susceptible to oxidative stress. Oxidative stress is an imbalance between the antioxidant defenses and the reactive oxygen in cells. It also causes damage to the cell structures in the mitochondria. Paraquat has been linked to the oxidative stress that creates this problem for the blood-brain barrier.[2]

Paraquat’s Redox Cycle

Paraquat toxicity is related to the ability to redox cycle, which accepts an electron from an appropriate donor with the subsequent reduction of oxygen to produce superoxide while also regenerating the parent compound.[3] The causal linkage between oxidative stress and Paraquat has been supported by multiple lines of experimental evidence regarding neurodegeneration.[4]

How is Paraquat Causally Linked to Parkinson’s

The blood-brain barrier is significant when discussing the circumstances behind the causal linkage of Paraquat and Parkinson’s disease. Typically, the blood-brain barrier protects the brain tissue from being exposed to harmful oxidative stress agents that can injure or cause damage to the brain tissue. However, that blood-brain barrier is not protective of the hypothalamus, pineal gland, and other areas. This leaves an opening for the type of damage that can occur from the oxidative stress caused by Paraquat. Thus, the brain is not protected by the blood-brain barrier.  

Symptoms of Paraquat Poisoning

According to the CDC, people who experience paraquat poisoning will have severe pain and swelling of the mouth and throat, indigestion, dehydration, abnormalities of the intestines, heart failure, kidney failure, and other severe injuries.[5] These short-term, immediate symptoms that appear when exposed to Paraquat on your clothing or skin are mentioned above. The more long-term effects surrounding this litigation are symptoms of Parkinson’s and the injuries breach of the blood-brain barrier of this toxic herbicide.

Michael Brady Lynch Firm

If you or a loved one have been injured by Paraquat, please give us a call at 888-585-5970. We have professionals that are standing by to take your call and hear your story.

Read Part 2 of The Adverse Effects of Paraquat 

Read Part 1 of The Adverse Effects of Paraquat 

  [1] https://emergency.cdc.gov/agent/paraquat/basics/facts.asp

[2] Katarzyna Kuter et al, NeuroChem. Res. 2010.

[3] Derek A. Dreschel and Manisha Patel, Free Radic. Biol. Med. 2008

[4] McCormack et al., J. of NeuroChem.

[5] https://emergency.cdc.gov/agent/paraquat/basics/facts.asp

Injured on a Cruise Ship? Call Us

Injured on a Cruise Ship? Call Us

Cruise vacations promise relaxation and adventure, but accidents do happen. Injuries aboard cruise ships can range from minor incidents to severe accidents, raising complicated legal questions about liability and compensation.

read more
Suboxone Lawsuits: From Opioid Addiction Cure to MDL Defendant

Suboxone Lawsuits: From Opioid Addiction Cure to MDL Defendant

According to the National Center for Biotechnology Medicine, more people die from drug overdoses in the US than any other form of accidental death. Opioid overdoses outnumber the historical peak death rate of HIV, gun violence, and car crashes. There’s no doubt we’re in the middle of an opioid crisis. Often, people become addicted to this drug after a legitimate prescription to manage pain after surgery or a chronic pain condition.

read more
Video Game Lawsuits: Developers Face Legal Action for Addictive Gameplay

Video Game Lawsuits: Developers Face Legal Action for Addictive Gameplay

Over the past 20 to 30 years, studies and mainstream media outlets have blamed video games for desensitizing minors to violence, increased obesity rates, sedentary lifestyles, and mental health issues like depression and anxiety. Now, developers are facing video game lawsuits from gamers who have become addicted to video games. Learn more about video game addiction and what to do if you or a loved one have suffered from video game addiction below.

read more
Ozempic Lawsuit 2024: The Latest Updates

Ozempic Lawsuit 2024: The Latest Updates

The FDA has approved Ozempic, a medication manufactured by Dutch company Novo Nordisk, for treating type 2 diabetes. Many healthcare providers also prescribe Ozempic to their patients for weight management purposes. This is because the medication’s active ingredient, semaglutide, has been approved for weight loss treatments.

read more
PFAS Lawsuit Update: March 2024

PFAS Lawsuit Update: March 2024

Suboxone, a medication approved by the FDA for the treatment of opioid addiction, has garnered significant attention not just within medical circles but also in legal domains. Composed of buprenorphine and naloxone, Suboxone has been lauded for its effectiveness in reducing opioid withdrawal symptoms and cravings. However, its rise in use has been shadowed by a growing concern over its potential for abuse, dependency, and the risk of serious side effects.

read more
×
What Our Clients Are Saying